摘要

质粒介导的mcr-1基因编码赋予多粘菌素抗性的磷酸乙醇胺转移酶。 mcr-1基因与插入序列ISApl1（IS30家族）相关。 体外动员测定证明了复合转座子结构ISApl1-mcr-1-ISApl1的功能。 转座产生2-bp重复并发生在富含AT的DNA区域中。 这是首次报道通过转座展示mcr-1基因的移动性。

The plasmid-mediated mcr-1 gene encodes a phosphoethanolamine transferase that confers resistance to polymyxins. The mcr-1 gene is associated with insertion sequence ISApl1 (IS30 family). In vitro mobilization assays demonstrated the functionality of the composite transposon structure ISApl1-mcr-1-ISApl1. Transposition generated a 2-bp duplication and occurred in AT-rich DNA regions. This is the first report demonstrating the mobility of the mcr-1 gene by transposition.

http://aac.asm.org/content/61/7/e00127-17.short