摘要

胃肠道微生物群落的多样性和动态性代表了生物活性物质的巨大来源。其中包括细菌素，这是一种抗菌肽，具有调节肠道菌群对人体健康产生积极影响的潜力。尽管已经分离出几种肠道来源的细菌素，但仅有少数例外的研究，其中研究了它们对肠道内微生物种群的影响。为了便于这种研究，体外粪便发酵系统可以用来模拟结肠的厌氧环境。在这种情况下，这种系统被用于探索唾液乳杆菌肠道分离株产生的新型广谱类IId细菌素bactofencin A对肠道种群和总体微生物多样性的影响。研究表明，尽管细菌毒素A是一种广谱细菌素，但它对肠道菌群的影响相对较小，对厌氧菌群如拟杆菌、梭菌和双歧杆菌有潜在的积极影响。所采取的策略是研究使用细菌毒素A以有益健康的方式操纵肠道微生物群的优点的重要的第一步。

The diverse and dynamic microbiota of the gastrointestinal tract represents a vast source of bioactive substances. These include bacteriocins, which are antimicrobial peptides with the potential to modulate gut populations to impact positively on human health. Although several gut-derived bacteriocins have been isolated, there remain only a few exceptional studies in which their influence on microbial populations within the gut has been investigated. To facilitate such investigations, in vitro faecal fermentation systems can be used to simulate the anaerobic environment of the colon. In this instance, such a system was employed to explore the impact of bactofencin A, a novel broad spectrum class IId bacteriocin produced by gut isolates of Lactobacillus salivarius, on intestinal populations and overall microbial diversity. The study reveals that, although bactofencin A is a broad spectrum bacteriocin, it has a relatively subtle influence on intestinal communities, with a potentially positive impact on anaerobic populations such as Bacteroides, Clostridium and Bifidibacterium spp. The strategy taken is an important first step in investigating the merits of using bactofencin A to manipulate the gut microbiota in a beneficial way for health.

https://www.sciencedirect.com/science/article/pii/S1075996416300531