摘要

Microplastics have become emerging contaminants, causing widespread concern about their potential toxic effects. In this study, the uptake and tissue accumulation of polystyrene microplastics (PS-MPs) in zebrafish were detected, and the toxic effects in liver were investigated. The results showed that after 7 days of exposure, 5 μm diameter MPs accumulated in fish gills, liver, and gut, while 20 μm diameter MPs accumulated only in fish gills and gut. Histopathological analysis showed that both 5 μm and 70 nm PS-MPs caused inflammation and lipid accumulation in fish liver. PS-MPs also induced significantly increased activities of superoxide dismutase and catalase, indicating that oxidative stress was induced after treatment with MPs. In addition, metabolomic analysis suggested that exposure to MPs induced alterations of metabolic profiles in fish liver and disturbed the lipid and energy metabolism. These findings provide new insights into the toxic effects of MPs on fish.

微塑料已成为新兴的污染物，引起广泛关注其潜在的毒性效应。本文研究了聚苯乙烯微塑料（PS MPS）在斑马鱼体内的摄取和组织积累，并对其在肝脏中的毒性作用进行了研究。结果表明，暴露7天后，鱼鳃、肝脏和肠道中积累5μm直径的MPS，而仅在鱼鳃和肠中积累20μm直径的MPS。组织病理学分析表明，5μm和70 nm PS -mPS均能引起鱼类肝脏炎症和脂质沉积。PS MPS还诱导了超氧化物歧化酶和过氧化氢酶活性的显著升高，表明MPS治疗后氧化应激的发生。此外，代谢组学分析表明，暴露于MPS诱导鱼类肝脏代谢谱的改变，并干扰脂质和能量代谢。这些发现为MPS对鱼类的毒性作用提供了新的见解。

https://pubs.acs.org/doi/abs/10.1021/acs.est.6b00183