摘要

尽管抗生素耐药性对全球人类和环境健康构成了重大且日益严重的威胁，但噬菌体（噬菌体）对环境中抗生素抗性基因（ARG）的获得和传播的贡献尚未得到广泛研究。 在这项研究中，对来自不同海洋生境的几种病毒体进行了全面分析，以研究噬菌体是否携带ARG。 该分析提供了强有力的证据，证明来自海洋生境的噬菌体是ARG的潜在储存库。 事实上，在所有分析的海洋病毒体中都发现了赋予对氨基香豆素，杆菌肽和多药耐药性（特别是mexB基因）抗性的基因。 鉴于此，考虑到噬菌体的全球分布，不应低估噬菌体作为ARG储库的作用。

Although antibiotic resistance represents a significant and growing threat to human and environmental health worldwide, the contribution of bacteriophages (phages) to the acquisition and spread of antibiotic resistance genes (ARGs) in the environment has not been extensively explored. In this study, a comprehensive analysis of several viromes from diverse marine habitats was performed to investigate whether or not phages carry ARGs. The analysis provides strong evidence that phages from marine habitats are potential reservoirs of ARGs. In fact, genes conferring resistance to aminocoumarin, bacitracin and multidrug resistance (particularly the mexB gene) were found in all analyzed marine viromes. Given this, the role of phages as reservoirs of ARGs should not be underestimated considering their global distribution.

https://www.ncbi.nlm.nih.gov/pubmed/30447583