摘要

    本文采用三维生物膜电极反应器（3D-BERs）对磺胺嘧啶（SDZ）、环丙沙星（CIP）与锌共渗废水进行了高效处理。结果表明，靶向抗生素和锌的共暴露增加了靶向耐药基因（ARGs）的绝对丰度和相对丰度。与普通厌氧反应器相比，3D-BER反应器阴极的目标ARGs丰度更高，出水总ARGs丰度降低。同时，冗余分析结果表明，锌和抗生素的积累对阴极携带ARGs的细菌群落组成有很大的影响，影响了ARGs丰度的变化。另外，通过网络分析发现ARGs及其宿主菌在从废水中去除时部分沉积在电极基质上。因此，3D-BER具有同时消除抗生素和锌的能力，大大降低了ARGs传播的风险。

     Three-dimensional biofilm electrode reactors (3D-BERs) with high treatment efficiency were constructed to treat wastewater containing sulfadiazine (SDZ) and ciprofloxacin (CIP) coexposure with Zinc (Zn). The results showed that coexposure to target antibiotics and Zn increased the absolute and relative abundances of target antibiotic resistance genes (ARGs). Additionally, the target ARG abundances were higher on cathode of 3D-BER compared with ordinary anaerobic reactor while the abundances of total ARGs were decreased in the effluent. Meanwhile, redundancy analysis results revealed that the composition of bacteria carrying ARGs was greatly influenced in the cathode by the accumulation of Zn and antibiotic, which dominated the changes of ARG abundances. Additionally, ARGs with their host bacteria revealed by network analysis were partially deposited on electrode substrates when being removed from wastewater. Thus, 3D-BER exhibits capability of simultaneously eliminating antibiotic and Zn, and greatly reduces the risks of ARGs spread.

     https://www.sciencedirect.com/science/article/abs/pii/S0960852419315202