摘要

抗生素耐药性给全世界的健康专业人员带来了严峻的挑战，有可能给现代卫生保健带来重大问题，导致更多的医疗支出、延长住院时间以及增加发病率和死亡率。先进的基因组测序技术呈现出一幅复杂的耐药性图景，使我们的理解超越了病原体和抗生素之间的药物治疗界面。本文讨论了抗生素耐药性的全球范围和规模，并结合牙科医生的情况，强调我们必须通过抗生素管理和疾病预防来限制耐药性的发展。

Antibiotic resistance presents a daunting challenge to health professionals worldwide and has the potential to create major problems for modern health care, resulting in more medical expenditure, extended hospital stays and increased morbidity and mortality. Advanced genome sequencing technologies present a complex picture of resistance, extending our understanding beyond the pharmacotherapeutic interface between pathogens and antibiotics. This review discusses the global scope and scale of antibiotic resistance and contextualizes it for the dental practitioner, emphasizing the role we must play in limiting the progression of resistance through antibiotic stewardship and disease prevention.

https://onlinelibrary.wiley.com/doi/abs/10.1111/adj.12727