摘要

    人们对河口的抗生素抗性基因（ARG）及其相关环境因素的发生了解甚少。 在这项研究中，我们全面分析了中国长江口进出口之间的水和沉积物中的ARGs。 最大浊度区（TMZ）中ARGs的相对丰度高于其他位置，这表明悬浮颗粒物（SPM）是水中ARGs的主要储集层。 ARGs显示出沉积物从入口到出口的增加趋势。 水和沉积物中的intI1和sul1之间呈正相关，表明sul1可能受intI1调控。 相关性分析和冗余分析表明，河口ARGs的空间变化与样品特性（例如温度，SPM，pH）和化学污染物（例如重金属和抗生素残留物）呈正相关，其中化学污染物是导致这些因素的主要因素。 水和沉积物中的ARG分布

    The occurrence of antibiotic resistance genes (ARGs) and their associated environmental factors in estuaries are poorly understood. In this study, we comprehensively analyzed ARGs in both water and sediments from inlet to outlet of the Yangtze Estuary, China. The relative abundances of ARGs were higher in the turbidity maximum zone (TMZ) than other sites, implying that suspended particulate matter (SPM) was the major reservoir for ARGs in water. ARGs showed an increasing trend from inlet to outlet in sediments. Positively correlation between intI1 and sul1 in both water and sediments indicated that sul1 may be regulated by intI1. Correlation analysis and redundancy analysis showed that the spatial variations of estuarine ARGs were positively correlated with sample properties (e.g., temperature, SPM, pH) and chemical pollutants (e.g., heavy metals and antibiotic residues), among which chemical pollutants were the major drivers for the ARG distribution in both water and sediments.

    https://www.sciencedirect.com/science/article/abs/pii/S0025326X20304781