摘要

       由于对人类健康和生态环境的严重威胁，抗生素已成为全球关注的焦点。本综述总结了污水处理厂 (WWTP) 中生物处理技术和联合工艺对抗生素和抗生素抗性基因 (ARG) 的归宿。吸附和生物降解是抗生素的两条主要去除途径。吸附是四环素类、氟喹诺酮类和大环内酯类抗生素去除的主要机制，而生物降解是磺胺类和β-内酰胺类抗生素去除的主要途径。此外，微生物共代谢过程有助于抗生素的生物降解。在污水处理厂中，提供了不同生物处理技术的抗生素去除途径和ARGs积累。讨论了施工和设置的简便性、操作的简单性、适应波动的灵活性、资本和运营成本。总体而言，联合技术应进一步研究，因为未来在抗生素治疗和减轻 ARGs 风险方面具有巨大的应用前景。

       Antibiotics have become a critical concern worldwide due to the severe threats to human health and eco-environment. This review summarizes the fate of antibiotics and antibiotics resistance genes (ARGs) by biological treatment technologies and combined processes in wastewater treatment plants (WWTPs). Adsorption and biodegradation are the two major removal pathways for antibiotics. Adsorption is the main mechanism of antibiotics removal for Tetracyclines, Fluoroquinolones and Macrolides, while biodegradation is the pathway of antibiotics removal for Sulfonamides and β-Lactams. Additionally, the microbial co-metabolism process contributes to the biodegradation of antibiotics. In WWTPs, the antibiotics removal pathway and ARGs accumulation by different biological treatment technologies were provided. The ease of construction and set-up, simplicity of operation, flexibility in adapting to the fluctuations, capital and operating costs were discussed. Overall, the combined technologies should be further investigated as great application prospects in the treatment of antibiotics and alleviation of ARGs risk in the future.

https://www.sciencedirect.com/science/article/abs/pii/S0048969721009736