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中国渤海湾沿岸地区抗生素抗性基因的发生与分布

发布者:抗性基因网 时间:2021-07-05 浏览量:461

摘要

       考虑到世界范围内抗生素的滥用,我们调查了渤海湾水域和沉积物中三类抗生素抗性基因(ARGs)的丰度和相应抗生素的浓度。 结果表明,在所有样品中均检测到sulI和sulII,其丰度范围为10-5-10-2/16S基因拷贝。 tetM 和 ermB 的丰度相对高于 tet-ARGs 和 erm-ARGs 的其他基因。 磺胺类抗生素是最普遍的抗生素,沉积物中抗生素的浓度高于水中的抗生素浓度。 相关性分析表明抗生素与相应的ARGs具有相关性,表明抗生素在ARGs的产生和转移中起重要作用。 回归分析结果表明,I类整合子促进了sulI和sulII的传播和维持。 

       Considering the abuse of antibiotics worldwide, we investigated the abundance of three classes of antibiotic resistance genes (ARGs) and the concentrations of corresponding antibiotics in water and sediments of Bohai Bay. The results showed that sulI and sulII were detected in all samples, and their abundance range was 10− 5–10− 2/16S gene copies. The abundance of tetM and ermB were relatively higher than the other genes of tet-ARGs and erm-ARGs. Sulfonamides were the most prevalent antibiotics, and the concentrations of antibiotic in sediments were higher than those in water. The correlation analysis revealed that antibiotics had pertinence with corresponding ARGs, indicating that antibiotics play an important role in the creation and transfer of ARGs. The results of regression analysis indicated that the propagation and maintenance of sulI and sulII were facilitated by class I integrons.

https://www.sciencedirect.com/science/article/abs/pii/S0025326X16301965