摘要

       抗生素在水产养殖中的广泛使用可能会导致抗生素抗性基因（ARGs）的出现，并通过进入食物链威胁人类健康。 为了评估抗生素在中国造成的环境风险，根据水源、池塘水和 8 个池塘的沉积物中 11 种 ARG 的丰度，确定了 8 种抗生素的时空分布和相关性。 结果表明，sul1是水源和池塘水中的主要ARG，沉积物中tetC最多。 随着饲养密度和池塘年龄的增加，观察到 ARGs 丰度增加的趋势。 与单一养殖相比，对虾养殖与不同营养水平的鱼类养殖相结合会影响 ARGs 的丰度。 沉积物中ARGs的丰度与抗生素浓度之间也存在显着相关性，而在水源和池塘水中没有观察到相关性。 

       The widespread use of antibiotics in aquaculture can potentially lead to the emergence of antibiotic resistance genes (ARGs) and threaten human health by entering the food chain. To assess the environmental risk posed by antibiotics in China, the spatial-temporal distribution and correlation of 8 antibiotics based on the abundance of 11 ARGs in water sources, pond water, and sediment in 8 ponds were determined. The results indicated that sul1 was the predominant ARG in water sources and pond water, and tetC was the most in the sediment. A trend of increasing abundance of ARGs was observed with increased rearing density and pond age. Compared to monoculture, shrimp culture integrated with different trophic levels of fish farming could influence the abundance of ARGs. There was also a significant correlation between the abundance of ARGs and antibiotic concentration in the sediment, while no correlation was observed in water sources and pond water.

https://www.sciencedirect.com/science/article/abs/pii/S0025326X18308142