摘要

       几十年来，抗生素一直被排放到污水处理厂 (WWTP) 中。 因此，在全球不同的污水处理厂中广泛检测到多种抗生素。 广泛应用的生物处理工艺为抗生素抗性基因（ARG）的发展和亚抑制抗生素浓度下的水平基因转移创造了有利条件。 目前，世界各地污水处理厂进出水中均检出β-内酰胺类、磺胺类、喹诺酮类（氟喹诺酮类）、四环素类、大环内酯类等六类抗生素。 污水处理厂中可以检测到自然环境和粪便样本中的很大一部分 ARGs，并且污水处理厂中的 ARGs 水平与粪便来源相当。 这些结果表明，污水处理厂作为 ARGs 传播热点的作用需要进一步综合研究，以制定抗击阻力的综合策略。

       Antibiotics have been discharged into wastewater treatment plants (WWTP) for decades. Therefore, multiple antibiotics have been widely detected in different sewage treatment plants around the world. The widely used biological treatment process has created favorable conditions for the development of antibiotic resistance genes (ARG) and horizontal gene transfer at sub-inhibitory antibiotic concentrations. At present, six types of antibiotics including β-lactams, sulfonamides, quinolones (fluoroquinolones), tetracyclines, and macrolides have been detected in the incoming and outgoing water of sewage treatment plants all over the world. A large part of the ARGs in the natural environment and fecal samples can be detected in the sewage treatment plant, and the level of ARGs in the sewage treatment plant is comparable to the source of feces. These results indicate that the role of sewage treatment plants as a hot spot for the spread of ARGs requires further comprehensive research to develop a comprehensive strategy to combat resistance.

http://resistancecontrol.info/2016/amr-in-food-water-and-the-environment/antibiotics-and-resistance-genes-in-wastewater-treatment-plants/