摘要

       软骨退化是关节炎疾病的标志。软骨的主要成分是蛋白聚糖和 II 型胶原蛋白。以前的研究表明，聚集蛋白聚糖的降解先于 II 型胶原蛋白降解，并且聚集蛋白聚糖的只有聚集蛋白聚糖酶降解而不是基质金属蛋白酶 (MMP) 降解是可逆的1。因此，必须拥有能够检测可逆和不可逆蛋白聚糖降解的生物标志物，以识别软骨状况。众所周知的聚集蛋白聚糖酶降解位点 NITEGE373_374ARGS 中，ARGS 仅由聚集蛋白聚糖酶释放，但 NITEGE 保留在聚集蛋白聚糖分子中，理论上需要额外的聚集蛋白聚糖降解才能释放。数字表示蛋白聚糖酶切割位点。
       Cartilage degeneration is a hallmark of arthritis disease. The main components of cartilage are proteoglycans and type II collagen. Previous studies have shown that the degradation of aggrecan precedes the degradation of type II collagen, and that only aggrecanase degradation rather than matrix metalloproteinase (MMP) degradation is reversible1. Therefore, it is necessary to have biomarkers capable of detecting reversible and irreversible proteoglycan degradation to identify cartilage conditions. In the well-known aggrecanase degradation site NITEGE373_374ARGS, ARGS is only released by aggrecanase, but NITEGE remains in the aggrecan molecule and theoretically requires additional aggrecan degradation to release. The number indicates the proteoglycanase cleavage site. 

https://ard.bmj.com/content/75/Suppl_2/955.1.short