摘要

       抗生素抗性基因 (ARG) 残留和海洋环境中的传播方式尚不清楚。分析了北黄海海水和沉积物中磺胺（SAs）浓度、不同基因和总细菌丰度。结果显示基因 sul I 和 sul II 在所有样品中都以相对较高的浓度存在，而基因 sul III 的检测量较少。沉积物中的 ARGs 浓度是水中的 103 倍，表明沉积物是必不可少的 ARG 库。统计分析显示抗生素总浓度与基因sul I和sul II的相对丰度呈正相关。基因sul I和基因sul II的相对丰度也与基因int1的相对丰度呈正相关。这种相关性表明 SA 对这些 ARG 施加了选择压力，而基因 int1 可能与基因 sul I 和 sul II 在海洋环境中的繁殖有关。

       The residue of antibiotic resistance genes (ARG) and the mode of transmission in the marine environment are unclear. The concentration of sulfonamides (SAs), different genes and total bacterial abundance in the seawater and sediments of the North Yellow Sea were analyzed. The results show that the genes sul I and sul II are present in relatively high concentrations in all samples, while the amount of gene sul III detected is small. The concentration of ARGs in the sediment is 103 times that of the water, indicating that the sediment is an essential ARG reservoir. Statistical analysis showed that the total concentration of antibiotics was positively correlated with the relative abundance of genes sul I and sul II. The relative abundance of gene sul I and gene sul II is also positively correlated with the relative abundance of gene int1. This correlation indicates that SA exerts selective pressure on these ARGs, and the gene int1 may be related to the reproduction of the genes sul I and sul II in the marine environment. 

https://www.sciencedirect.com/science/article/abs/pii/S0025326X14003178