摘要
      爱德华七世菌在水生环境中要么以个体浮游细胞的形式存在，要么以公共生物膜的形式存在。这些生物会遇到多种压力，包括盐度、pH值、温度和营养物质的变化。致病性物种，如E.piscicida，可以在鱼类宿主体内繁殖。此外，爱德华氏菌（E.tarda）可以在染色体和/或质粒上携带抗生素抗性基因（ARGs），这些基因可以通过水平基因转移传递给微生物组。E.tarda是水生抗性的核心。爱德华七世使用分子开关（RpoS和EsrB）来控制基因表达，以在不同的环境中生存。我们推测，使用类似的分子开关，自由生活的爱德华七世菌可以过渡到宿主生活，反之亦然。了解这种转变可以帮助我们了解其他类似的水生细菌是如何从自由生活转变为病原体的。这些知识可以用来设计减缓ARGs传播的方法，并防止水产养殖和临床环境中的疾病爆发。
ABSTRACT
Edwardsiella species in aquatic environments exist either as individual planktonic cells or in communal biofilms. These organisms encounter multiple stresses, include changes in salinity, pH, temperature, and nutrients. Pathogenic species such as E. piscicida, can multiply within the fish hosts. Additionally, Edwardsiella species (E. tarda), can carry antibiotic resistance genes (ARGs) on chromosomes and/or plasmids, that can be transmitted to the microbiome via horizontal gene transfer. E. tarda serves as a core in the aquatic resistome. Edwardsiela uses molecular switches (RpoS and EsrB) to control gene expression for survival in different environments. We speculate that free-living Edwardsiella can transition to host-living and vice versa, using similar molecular switches. Understanding such transitions can help us understand how other similar aquatic bacteria switch from free-living to become pathogens. This knowledge can be used to devise ways to slow down the spread of ARGs and prevent disease outbreaks in aquaculture and clinical settings.

https://www.tandfonline.com/doi/full/10.1080/21505594.2021.2006890